Pro-apoptotic Activity of Novel Isatin-Schiff Base Copper(II) Complexes Depends on Oxidative Stress Induction and Organelle-selective Damage
نویسندگان
چکیده
منابع مشابه
Pro-apoptotic activity of novel Isatin-Schiff base copper(II) complexes depends on oxidative stress induction and organelle-selective damage.
We characterized the pro-apoptotic activity of two new synthesized isatin-Schiff base copper(II) complexes, obtained from isatin and 1,3-diaminopropane or 2-(2-aminoethyl)pyridine: (Cu(isapn)) and (Cu(isaepy)(2)), respectively. We demonstrated that these compounds trigger apoptosis via the mitochondrial pathway. The early induction of the p53/p21 system indicates a role for p53 in cell death, h...
متن کاملBidentate Isatin Schiff Base Ligands Oxovanadium (IV) Complexes
The aim of the present study is to synthesize the oxovanadium complex of the V3+ ion with isatin sciff bases. Spectroscopic methods have been used to confirm these models of complexation and to understand the structures of the species formed in methanolic solution. We also have isolated a complex of Vanadium (III) with isatin schiff bases in the solid phase.
متن کاملBidentate Isatin Schiff Base Ligands Oxovanadium (IV) Complexes
The aim of the present study is to synthesize the oxovanadium complex of the V3+ ion with isatin sciff bases. Spectroscopic methods have been used to confirm these models of complexation and to understand the structures of the species formed in methanolic solution. We also have isolated a complex of Vanadium (III) with isatin schiff bases in the solid phase.
متن کاملBidentate Isatin Schiff Base Ligands Oxovanadium (IV) Complexes
The aim of the present study is to synthesize the oxovanadium complex of the V3+ ion with isatin sciff bases. Spectroscopic methods have been used to confirm these models of complexation and to understand the structures of the species formed in methanolic solution. We also have isolated a complex of Vanadium (III) with isatin schiff bases in the solid phase.
متن کاملSynthesis and Characterization of Novel Lead (II) Complexes with Schiff Base Iminopyridine Ligand
First, Schiff base iminopyridine ligand has been prepared by the condensation between primary amine, dimethylaniline and active carbonyl group of pyridine carboxaldehyde, then related complexes were synthesized in methanol solution. The ligand and metal complexes have been characterized by elemental analysis, UV, IR, 1 H NMR and 13CNMR spectroscopy. The spectroscopic data of metal complexes ind...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2007
ISSN: 0021-9258
DOI: 10.1074/jbc.m610927200